Fourth Covid vaccine dose shown to boost antibodies, says Israeli PM

A fourth dose of a Covid-19 vaccine will increase antibodies within the blood fivefold after one week, Israel’s prime minister mentioned, citing a preliminary research the day after the nation started rolling out the jabs.

Israel started providing a fourth dose of the BioNTech/Pfizer vaccine on Monday to Israelis over the age of 60 and medical employees amid spiking case numbers due to the Omicron coronavirus variant.

Prime Minister Naftali Bennett mentioned the findings of the research, by Israeli researchers, have been promising.

“First of all, the fourth dose is safe. It’s a safety parameter similar to what we saw after the third dose — that’s good news,” Bennet mentioned on Tuesday at Sheba Medical Center the place the research was performed.


“A week after taking the fourth dose we see a meaningful rise in the number of antibodies, a fivefold increase within one week,” he mentioned. “That’s an indicator of a very high likelihood that the fourth dose will protect . . . against infection to some degree and against severe symptoms.”

The research was carried out on 154 folks from Sheba Medical Center who exhibited low antibodies and who obtained the third “booster” jab of the Pfizer vaccine earlier than August 20. Other preliminary research from Israel instructed that vaccine effectiveness wanes after three to 4 months.

The European Medicines Agency signalled late final 12 months that it was reviewing whether or not fourth doses have been wanted for a subset of at-risk populations, akin to those that are immunocompromised. Immunocompromised folks within the UK can obtain a fourth dose.

UK well being officers have mentioned they’re reviewing the accessible proof on whether or not this needs to be expanded to the final inhabitants.


Israel was the primary nation on the planet to rollout a 3rd shot final July, a transfer that was credited with halting the earlier Delta variant wave. The fourth jab is now being supplied to those that each meet the factors and obtained the third shot greater than fourth months in the past.

The authorities and well being authorities have mentioned the primary intention of the fourth jab rollout is to protect essentially the most weak folks from extreme sickness and demise, keep away from the collapse of the well being system and maintain the financial system open.

As of Monday, the primary day it was on supply, about 100,000 eligible Israelis both obtained the vaccine shot or had already made appointments to achieve this.


More than 10,000 new Covid instances have been reported in Israel on Monday, the best each day determine since September and a 10-fold improve from mid-December. The variety of severely unwell folks has elevated at a way more gradual tempo and stood at 117 on Tuesday, of which 92 weren’t thought-about to be totally vaccinated in accordance to well being ministry information.

While research present that repeated boosting prevents an infection, rising proof suggests double vaccination, with out boosters, can nonetheless shield towards extreme illness, even when attributable to Omicron.

A Harvard college research this week discovered mobile immunity remained sturdy towards the variant. The discovering is likely one of the many items of proof that may assist world well being authorities resolve whether or not Omicron-targeted vaccines will change into needed.

Additional reporting by Oliver Barnes in London

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